Charles Panati was born in Baltimore, MD, and raised in Atlantic City, NJ. His family had worked with the Miss America Pageant, and in his early twenties Panati worked as an escort for pageant contestants. In 1965 he received a B.S. in physics from Villanova University, and in 1966 he received a M.Sc. in Radiation Health Physics from Columbia University. After graduating, he worked in cancer research at the Columbia Presbyterian Hospital.
In 1971 he became a science reporter for Newsweek Magazine. He became interested in parapsychology and his first book , Supersenses: Our Potential for Parasensory Experience (1974) was about extrasensory perception. He followed up with other fringe science books: The Geller Papers (1976), which was about the Israeli psychic Uri Geller; Death Encounters (1979), about the "white light" phenomenon reported by some people who have been resuscitated from the verge of death; and Breakthroughs: Advances in Science, Medicine and Technology (1980), about future developments in technology. He also wrote the psychological suspense novels Links (1978) and The Pleasuring of Rory Malone (1982).
Following the 1979 accident at the Three Mile Island Nuclear Generating Station in Pennsylvania happened, he co-wrote the book The Silent Intruder: Surviving the Radiation Age …